Danchenko E.O. Biochemistry

Course of lectures. — Gomel: VSMU Press, 2004. — 360 р.The course of the lectures is designed for students of higher medical educational establishments. The lectures can beused as an integrated curriculum in which ready access to biochemical information is required.
The course of lectures corresponds with typical educational plan and program proved by Ministry of Health Care of Republic of Belarus.
Introduction to biochemistry. Structure and function of proteins.
Structure of proteins.
Purification of proteins.
General characteristics of enzymes.
Activators of enzymes. Enzyme inhibition. Enzyme regulation.
Membranes. Transport systems.
Introduction to metabolism. Nutrition.
Bioenergetics. Biologic oxidation. Respiratory chain.
Oxidative phosphorylation.
Peroxydase pathways. Monooxygenase systems. Dioxygenase system.
Free radicals and antioxydants. Common pathway of metabolism (cycle citric acid).
Metabolism of carbohydrates. Metabolism of glucose under aerobic conditions.
Metabolism of carbohydrates. Metabolism glucose under anaerobic condition. Gluconeogenesis. Pentose phosphate pathway.
Metabolism of carbohydrates. Metabolism of glycogen. Metabolism of fructose and galactose.
Metabolism of lipids. Eicosanoids. Digestion of lipids. Lipid transport. Fatty acid oxidation.
Metabolism of lipids. Biosynthesis of fatty acid. Biosynthesis of cholesterol. Ketone bodies metabolism.
Metabolism of lipids. Metabolism of triacylglycerols and glycerophospholipids. Cholesterol transport. Disorders of plasma lipoproteins. Fatty liver. Obesity. Atherosclerosis.
Metabolism of amino acids. Transamination and deamination of amino acids.
Metabolism of amino acids. Urea cycle. Decarboxylation of amino acids.
Metabolism of amino acids. Transmethylation. Metabolism of phenylalanine and tyrosine.
Structure of nucleic acids.
Metabolism of purine and pyrimidinenucleotides.
Nucleic acid metabolism. Replication. DNA repair. Transcription.
Translation. Regulation of gene expression. Mutations.
Mechanism of hormone action. Hormone of hypothalamus and pituitary.
Mechanism of hormone action. Hormone of hypothalamus and pituitary.
Hormonal regulation of anabolic processes, growth and development.
Minerals. Metabolism and regulation of calcium and phosphorous metabolism. Regulation of electrolyte and water balance.
Integration of metabolism.
Overview of vitamins. Fat-soluble vitamins.
Water-soluble vitamins: C, B₁ B₂, B₆, niacin.
Water-Soluble Vitamins: biotin, folic acid, B₁₂,pantothenicacid.
Water-Soluble Vitamins: biotin, folic acid, B₁₂,pantothenicacid.
Extracellular matrix.
Muscle.
Cancerogenesis. Oncogenes. Growth factors.
Metabolism of xenobiotics.