Souba Wiley W., Wilmore Douglas W. (eds.) Surgical Research

Academic Press, 2001. — 1429 p. — ISBN: 978-0-12-655330-7With the recent changes in the health care industry, surgeons face increasing pressure to devote their time to their clinical activities, thus limiting their research efforts. It is essential that young and creative individuals are encouraged to perform research and are given incentives to participate in research under the mentorship of more experienced research investigators.Surgical Research is the first book to include all the information necessary for the surgical scientist to perform a research experiment. The editors have assembled outstanding, expert investigators in multiple surgical fields and asked them to describe how they achieve their research accomplishments. In Surgical Research, these experts in the field have outlined everything involved in preparing and conducting a research project. Some of the topics covered in the book include how to state a research question, how to review the available information, how to write research protocol, how to obtain grant money for the experiment, how to analyze the data, and how to present the findings. Also discussed are the ethics of animal and human experimentation along with the history and philosophy of surgical research.To continue to advance technologies and surgical methods, research must continually be performed. Potentially great discoveries are being missed because would-be researchers do not know where to start or how to conduct research, and therefore do not even try. This book provides prospective researchers with all the basic steps needed to perform a research experiment in the surgical field. No student, resident, or fellow should start a research project without this book and no senior surgical scientist should be without it occupying a prominent position in the library.Getting Started
Assessing Available Information
Organizing and Preliminary Planning for Surgical Research
Writing a Protocol: Animals, Humans, and Use of Biologic, Chemical, and Radiologic Agents
Grantsmanship
Informed Consent and the Protection of Human Research Subjects: Historical Perspectives and Guide to Current United States Regulations
Animal Care and Maintenance
Funding Strategies and Agencies: Academic-Industrial Relationships; Intellectual Property
Statistical Considerations
Use of Nonexperimental Studies to Evaluate Surgical Procedures and Other Interventions: The Challenge of Risk Adjustment
Measuring Surgical Outcomes
Design of Clinical Trials
Using Administrative Data for Clinical Research
Research in the Intensive Care Unit: Ethical and Methodological Issues
Research in the Operating Room
Effects of Age and Gender
Strategies, Principles, and Techniques Using Transgenic and Knockout Mouse Models
Tissue Culture, Cell Growth, and Analysis
Hematopoietic Stem Cells: Basic Concepts and Applications to Surgical Research
Basic Molecular Biological Methods in Surgical Research: Genetic Library Construction, Screening, and DNA Sequencing