Pauling L. Selected Scientific Papers. Vol. 2: Biomolecular Sciences

World Scientific, 2001. — 733 pp.Considered to be the most influential chemist of the 20th century, Linus Pauling (1901–1994) led the way in developing the modern concepts of chemical bonding and their fruitful application to all aspects of chemistry and then to biology and medicine. His ideas have fundamentally transformed the way chemistry is formulated as a science and taught, and have opened up completely new fields that have grown to immense importance, such as molecular biology and molecular disease. For this pioneering work he was awarded the Nobel Prize in Chemistry in 1954, and he received countless other prizes, medals, awards, honorary degrees, etc. In 1963 he was awarded the Nobel Prize for Peace in recognition of his successful efforts, based on scientific principles of radiation biology, to halt the testing of nuclear weapons in the atmosphere. Pauling is the only person to have received two unshared Nobel Prizes.
Linus Pauling wrote a stellar series of over 800 scientific papers spanning an amazing range of fields, some of which he himself initiated. This book is a selection of the most important of his writings in the fields of quantum mechanics, chemical bonding (covalent, ionic, metallic, and hydrogen bonding), molecular rotation and entropy, protein structure, hemoglobin, molecular disease, molecular evolution, the antibody mechanism, the molecular basis of anesthesia, orthomolecular medicine, radiation chemistry⁄biology, and nuclear structure. Through these papers the reader gets a fresh, unfiltered view of the genius of Pauling's many contributions to chemistry, chemical physics, molecular biology, and molecular medicine.Introduction to Volume II.
Biological Macromolecules
Introduction to Part III.
Hemoglobin: Oxygen Bonding and Magnetic Properties
The Oxygen Equilibrium of Hemoglobin and Its Structural Interpretation // Proc. Natl. Acad. Sci. USA 21, 186-191 (1935).
The Magnetic Properties and Structure of Hemoglobin, Oxyhemoglobin and Carbonmonoxyhemoglobin (by Linus Pauling and Charles D. Coryell) // Proc. Natl. Acad. Sci. USA 22, 210-216 (1936).
The Magnetic Properties and Structure of Ferrihemoglobin (Methemoglobin) and Some of Its Compounds (by C. D. Coryell, F. Stitt, and Linus Pauling) // J. Am. Chem Soc. 59, 633-642 (1937).
The Combining Power of Hemoglobin for Alkyl Isocyanides, and the Nature of the Heme-Heme Interactions in Hemoglobin (by Robert C. C. St. George and Linus Pauling) // Science 114, 629-634 (1951).
The Nature of the Iron-Oxygen Bond in Oxyhaemoglobin // Nature 203, 182-183 (1964).
The Normal Hemoglobins and Hemoglobinopathies: Background // Texas Reports on Biology and Medicine 40, 1-7 (1980-1981).
Antibodies: Structure and Function
A Theory of the Structure and Process of Formation of Antibodies // J. Am. Chem. Soc. 62, 2643-2657 (1940).
The Serological Properties of Simple Substances. I. Precipitation Reactions Between Antibodies and Substances Containing Two or More Haptenic Groups (by Linus Pauling, David Pressman, Dan H. Campbell, Carol Ikeda, and Miyoshi Ikawa) // J. Am. Chem. Soc. 64, 2994-3003 (1942).
The Serological Properties of Simple Substances. II. The Effects of Changed Conditions and of Added Haptens on Precipitation Reactions of Polyhaptenic Simple Substances (by Linus Pauling, David Pressman, Dan H. Campbell, and Carol Ikeda) // J. Am. Chem. Soc. 64, 3003-3009 (1942).
The Nature of the Forces Between Antigen and Antibody and of the Precipitation Reaction (by Linus Pauling, Dan H. Campbell, and David Pressman) // Physiol. Rev. 23, 203-219 (1943).
The Serological Properties of Simple Substances. VI. The Precipitation of a Mixture of Two Specific Antisera by a Dihaptenic Substance Containing the Two Corresponding Haptenic Groups; Evidence for the Framework Theory of Serological Precipitation (by Linus Pauling, David Pressman, and Dan H. Campbell) // J. Am. Chem. Soc. 66, 330-336 (1944).
Antibodies and Specific Biological Forces // Endeavour 7(26), 43-53 (1948).
The Reaction of Simple Antigens with Purified Antibody (by Arthur B. Pardee and Linus Pauling) // J. Am. Chem. Soc. 71, 143-148 (1949).
The Alpha Helix and the Structure of Proteins
On the Structure of Native, Denatured, and Coagulated Proteins (by A. E. Mirsky and Linus Pauling) // Proc. Natl. Acad. Sci. USA 22, 439-447 (1936).
The Structure of Proteins (by Linus Pauling and Carl Niemann) // J. Am. Chem. Soc. 61, 1860-1867 (1939).
The Structure of Proteins: Two Hydrogen-Bonded Helical Configurations of the Polypeptide Chain (by Linus Pauling, Robert B. Corey, and H. R. Branson) // Proc. Natl. Acad. Sci. USA 37, 205-211 (1951).
Atomic Coordinates and Structure Factors for Two Helical Configurations of Polypeptide Chains (by Linus Pauling and Robert B. Corey) // Proc. Natl. Acad. Sci. USA 37, 235-240 (1951).
The Structure of Synthetic Polypeptides (by Linus Pauling and Robert B. Corey) // Proc. Natl. Acad. Sci. USA 37, 241-250 (1951).
The Pleated Sheet, a New Layer Configuration of Polypeptide Chains (by Linus Pauling and Robert B. Corey) // Proc. Natl. Acad. Sci. USA 37, 251-256 (1951).
The Structure of Feather Rachis Keratin (by Linus Pauling and Robert B. Corey) // Proc. Natl. Acad. Sci. USA 37, 256-261 (1951).
The Structure of Hair, Muscle, and Related Proteins (by Linus Pauling and Robert B. Corey) // Proc. Natl. Acad. Sci. USA 37, 261-271 (1951).
The Structure of Fibrous Proteins of the Collagen-Gelatin Group (by Linus Pauling and Robert B. Corey) // Proc. Natl. Acad. Sci. USA 37, 272-281 (1951).
The Polypeptide-Chain Configuration in Hemoglobin and Other Globular Proteins // Proc. Natl. Acad. Sci. USA 37, 282-285 (1951).
The Planarity of the Amide Group in Polypeptides (by Robert B. Corey and Linus Pauling) // J. Am. Chem. Soc. 74, 3964 (1952).
Fundamental Dimensions of Polypeptide Chains (by R. B. Corey and Linus Pauling) // Proc. Roy. Soc. Lond. B 141, 10-20 (1953).
Stable Configurations of Polypeptide Chains (by Linus Pauling and R. B. Corey) // Proc. Roy. Soc. Lond. B 141, 21-33 (1953).
Compound Helical Configurations of Polypeptide Chains: Structure of Proteins of the alpha-Keratin Type (by Linus Pauling and R. B. Corey) // Nature 171, 59-61 (1953).
Two Rippled-Sheet Configurations of Polypeptide Chains, and a Note About the Pleated Sheets (by Linus Pauling and R. B. Corey) // Proc. Natl. Acad. Sci. USA 39, 253-256 (1953).
The Structure of Tussah Silk Fibroin (with a note on the structure of beta-poly-l-alanine) (by Richard E. Marsh, Robert B. Corey, and Linus Pauling) // Acta Cryst. 8, 710-715 (1955).
The Discovery of the alpha Helix // The Chemical Intelligencer 2(1), 32-38 (1996).
Molecular Biology: The Role of Large Molecules in Life and Evolution
The Nature of the Intermolecular Forces Operative in Biological Processes (by Linus Pauling and Max Delbruck) // Science 92, 77-79 (1940).
Molecular Architecture and Biological Reactions // The Journal of NIH Research 2(6), 59-64 (1990).
The Nature of Forces Between Large Molecules of Biological Interest // Nature 161, 707-709 (1948).
Molecular Architecture and the Processes of Life // Sir Jesse Boot Foundation, Nottingham, England, 13 pp. (1948).
A Proposed Structure for the Nucleic Acids (by Linus Pauling and Robert B. Corey) // Proc. Natl. Acad. Sci. USA 39, 84-97 (1953).
Specific Hydrogen-Bond Formation Between Pyrimidines and Purines in Deoxyribonucleic Acids (by Linus Pauling and R. B. Corey) // Arch. Biochem. Biophys. 56, 164-181 (1956).
A Comparison of Animal Hemoglobins by Triptic Peptide Pattern Analysis (by Emile Zuckerkandl, Richard T. Jones, and Linus Pauling) // Proc. Natl. Acad. Sci. USA 46, 1349-1360 (1960).
Molecular Disease, Evolution, and Genie Heterogeneity (by Emile Zuckerkandl and Linus Pauling) // In Horizons in Biochemistry, eds. Michael Kasha and Bernard Pullman, Academic Press, NY, pp. 189-225 (1962).
Chemical Paleogenetics: Molecular "Restoration Studies" of Extinct Forms of Life (by Linus Pauling and Emile Zuckerkandl) // Acta Chem. Scand. 17 (Suppl. no. 1), S9-S16 (1963).
Molecules as Documents of Evolutionary History (by Emile Zuckerkandl and Linus Pauling) // J. Theoret. Biol. 8, 357-366 (1965).
Health and Medicine
Introduction to Part IV.
Molecular Disease
Sickle Cell Anemia, a Molecular Disease (by Linus Pauling, Harvey A. Itano, S. J. Singer, and Ibert C. Wells) // Science 110, 543-548 (1949).
The Hemoglobin Molecule in Health and Disease // Proc. Am. Phil. Soc. 96, 556-565 (1952).
Abnormality of Hemoglobin Molecules in Hereditary Hemolytic Anemias // In The Harvey Lectures 1953-1954, Series 49, Academic Press, N.Y., pp. 216-241 (1955).
Abnormal Hemoglobin Molecules in Relation to Disease (by Harvey A. Itano and Linus Pauling) // Svensk Kemisk Tidskrift 69, 509-523 (1957).
Molecular Disease and Evolution // Proc. Rudolf Virchow Med. Soc. N.Y. 21, 131-140 (1963).
Physiological Chemistry, Effects of Radiation, and Health Hazards
Genetic and Somatic Effects of Carbon-14 // Sccience 128, 1183-1186 (1958).
The Effects of Strontium-90 on Mice (by Barclay Kamb and Linus Pauling) // Proc. Natl. Acad. Sci. USA 45, pp. 54-69 (1959).
A Molecular Theory of General Anesthesia // Science 134, 15-21 (1961).
Results of a Loading Test of Ascorbic Acid, Niacinamide, and Pyridoxine in Schizophrenic Subjects and Controls (by Linus Pauling, Arthur B. Robinson, Susanna S. Oxley, Maida Bergeson, Andrew Harris, Paul Cary, John Blethen, and Ian T. Keaveny) // In Orthomolecular Psychiatry: Treatment of Schizophrenia, eds. David Hawkins and Linus Pauling, W. H. Freeman, San Francisco, pp. 18-34 (1973).
The Discovery of the Superoxide Radical // Trends in Biochemical Sciences 4, 270-271 (1979).
Biostatistical Analysis of Mortality Data for Cohorts of Cancer Patients // Proc. Natl. Acad. Sci. USA 86, 3466-3468 (1989).
Criteria for the Validity of Clinical Trials of Treatments of Cohorts of Cancer Patients Based on the Hardin Jones Principle (by Linus Pauling and Zelek S. Herman) // Proc. Natl. Acad. Sci. USA 86, 6835-6837 (1989).
Orthomolecular Medicine
Orthomolecular Psychiatry: Varying the Concentrations of Substances Normally Present in the Human Body May Control Mental Disease // Science 160, 265-271 (1968).
Orthomolecular Somatic and Psychiatric Medicine // Vitalstoffe-Zivilisationskrankheiten 1/68, 3-5 (1968).
Evolution and the Need for Ascorbic Acid // Proc. Natl. Acad. Sci. USA 67, 1643-1648 (1970).
Ascorbic Acid and the Common Cold // Am. J. Clin. Nutr. 24, 1294-1299 (1971).
Orthomolecular Psychiatry // In Orthomolecular Psychiatry: Treatment of Schizophrenia, eds. David Hawkins and Linus Pauling, W. H. Freeman, San Francisco, pp. 1-17 (1973).
Ascorbic Acid and the Glycosaminoglycans: An Orthomolecular Approach to Cancer and Other Diseases (by Ewan Cameron and Linus Pauling) // Oncology 27, 181-192 (1973).
Supplemental Ascorbate in the Supportive Treatment of Cancer: Prolongation of Survival Times in Terminal Human Cancer (by Ewan Cameron and Linus Pauling) // Proc. Natl. Acad. Sci. USA 73, 3685-3689 (1976).
Ascorbic Acid and Cancer: A Review (by Ewan Cameron, Linus Pauling, and B. Leibovitz) // Cancer Research 39, 663-681 (1979).
Suppression of Human Immunodeficiency Virus Replication by Ascorbate in Chronically and Acutely Infected Cells (by Steve Harakeh, Raxit J. Jariwalla, and Linus Pauling) // Proc. Natl. Acad. Sci. USA 87, 7245-7249 (1990).
A Unified Theory of Human Cardiovascular Disease Leading the Way to the Abolition of this Disease as a Cause for Human Mortality (by Matthias Rath and Linus Pauling) // J. Orthomolecular Med. 7(1), 17-23 (1992).
Summary and Conclusions: The Role of Vitamin C in the Treatment of Cancer (by Ewan Cameron and Linus Pauling) // In Cancer and Vitamin C (Updated and Expanded Edition), Camino Books, Philadelphia, PA, Chapter 23, pp. 189-195 (1993).
Summary of Linus Pauling's Life and Scientific Work
Biographical Memoir, by Prof. Jack D. Dunitz.
List of Scientific Publications of Linus Pauling.