Greer J. (ed.). Wintrobe's Clinical Hematology

13th edition. — Wolters Kluwer Health, Lippincott Williams & Wilkins, 2013. — 5122 p. — ISBN13: 9781451172683.Welcome to the thirteenth edition of Wintrobe's Clinical Hematology. This textbook strives to continue the Wintrobe tradition of being comprehensive yet accessible to all who seek to understand the history, science, and clinical practice of hematology. We have brought together clinicians and scientists who have given their time and expertise to produce a state-of-the-art resource which includes an online presence with expanded bibliographies, appendices, and updates.
With the 13th edition of Wintrobe’s Clinical Hematology, this new edition once again bridges the gap between the clinical practice of hematology and the basic foundations of science.
Broken down into eight parts, this book provides readers with a comprehensive overview of: Laboratory Hematology, The Normal Hematologic System, Transfusion Medicine, Disorders of Red Cells, Hemostasis and Coagulation; Benign Disorders of Leukocytes, The Spleen and/or Immunoglobulins; Hematologic Malignancies, and Transplantation. Within these sections, there is a heavy focus on the morphological exam of the peripheral blood smear, bone marrow, lymph nodes, and other tissues.
With the knowledge about gene therapy and immunotherapy expanding, the book includes new, up-to-date information about the process and application of these therapies. Likewise, the editors have shed a completely new light on the process of stem cell transplantation in regards to both malignant and benign disorders, graft versus host disease, and the importance of long-term follow-up of transplantation survivors.
The textbook features an online, interactive companion that has a reference list for each chapter as well as two appendices one reviewing the clusters of differentiation (CD) molecules and one that reviews lab values and photomicrographs of the blood of animals.
Along with these tools, the authors plan to post updates online when they are particularly pertinent or important.Laboratory Hematology
Examination of the Blood and Bone Marrow
Clinical Flow Cytometry
Cytogenetics
Molecular Diagnosis in Hematology
The Normal Hematologic System
Hematopoiesis
Origin and Development of Blood Cells
The Erythrocyte
The Birth, Life, and Death of Red Blood Cells: Erythropoiesis, The Mature Red Blood Cell, and Cell Destruction
Granulocytes and Monocytes
Neutrophilic Leukocytes
The Human Eosinophil
Mast Cells and Basophils: Ontogeny, Characteristics, and Functional Diversity
Monocytes, Macrophages, and Dendritic Cells
The Lymphocytes
Lymphocytes and Lymphatic Organs
B Lymphocytes
T Lymphocytes and Natural Killer Cells
Effector Mechanisms in Immunity
Hemostasis
Megakaryocytes
Platelet Structure and Function in Hemostasis and Thrombosis
Platelet Function in Hemostasis and Thrombosis
Blood Coagulation and Fibrinolysis
Endothelium: Angiogenesis and the Regulation of Hemostasis
Transfusion Medicine
Red Cell, Platelet, and White Cell Antigens
Transfusion Medicine
Disorders of Red Cells
Introduction
Anemia: General Considerations
Disorders of Iron Metabolism and Heme Synthesis
Iron Deficiency and Related Disorders
Sideroblastic Anemias
Hemochromatosis
Porphyrias
Hemolytic Anemia
Hereditary Spherocytosis, Hereditary Elliptocytosis, and Other Disorders Associated with Abnormalities of the Erythrocyte Membrane
Hereditary Hemolytic Anemias Due to Red Blood Cell Enzyme Disorders
Autoimmune Hemolytic Anemia
Hemolytic Disease of the Fetus and Newborn
Paroxysmal Nocturnal Hemoglobinuria
Acquired Nonimmune Hemolytic Disorders
Hereditary Disorders of Hemoglobin Structure and Synthesis
Sickle Cell Anemia and Other Sickling Syndromes
Thalassemias and Related Disorders: Quantitative Disorders of Hemoglobin Synthesis Hemoglobins with Altered Oxygen Affinity, Unstable Hemoglobins, M-Hemoglobins, and Dyshemoglobinemias
Inherited Aplastic Anemia Syndromes
Acquired Aplastic Anemia
Red Cell Aplasia: Acquired and Congenital Disorders
Congenital Dyserythropoietic Anemias
Anemias Secondary to Chronic Disease and Systemic Disorders
Anemias During Pregnancy and The Postpartum Period
Anemias Unique to the Fetus and Neonate
Erythrocytosis
Disorders of Hemostasis and CoagulationDiagnostic Approach to the Bleeding Disorders
Thrombocytopenia
Thrombocytopenia: Pathophysiology and Classification
Thrombocytopenia Caused by Immunologic Platelet Destruction
Thrombotic Thrombocytopenic Purpura, Hemolytic-Uremic Syndrome, and Related Disorders
Miscellaneous Causes of Thrombocytopenia
Bleeding Disorders Caused by Vascular Abnormalities
Thrombocytosis and Essential Thrombocythemia
Qualitative Disorders of Platelet Function
Coagulation Disorders
Inherited Coagulation Disorders
Acquired Coagulation Disorders
Thrombosis
Thrombosis and Antithrombotic Therapy
Benign Disorders of Leukocytes, The Spleen, and/or Immunoglobins
Diagnostic Approach to Malignant and Nonmalignant Disorders of the Phagocytic and Immune Systems
Neutropenia
Qualitative Disorders of Leukocytes
Lysosomal Abnormalities of the Monocyte-Macrophage System: Gaucher and Niemann-Pick Diseases
Langerhans Cell Histiocytosis
Pathology of Langerhans Cell Histiocytosis and Other Histiocytic Proliferations
Infectious Mononucleosis and Other Epstein-Barr Virus-Related Disorders
Primary Immunodeficiency Syndromes
Acquired Immunodeficiency Syndrome
Disorders of the Spleen
Hematologic Malignancies
General Aspects
Hematopoietic Neoplasms: Principles of Pathologic Diagnosis
Principles and Pharmacology of Chemotherapy
Supportive Care in Hematologic Malignancies
Gene Therapy for Hematologic Disorders
The Acute Leukemias
Molecular Genetics of Acute Leukemia
Diagnosis and Classification of the Acute Leukemias and Myelodysplastic Syndromes
Acute Lymphoblastic Leukemia in Adults
Acute Myeloid Leukemia in Adults
Acute Lymphoblastic Leukemia in Children
Acute Myelogenous Leukemia in Children
Acute Promyelocytic Leukemia
Myelodysplastic Syndromes
Myeloproliferative Disorders
Pathology of the Myeloproliferative Neoplasms
Chronic Myeloid Leukemia
Polycythemia Vera
Myelofibrosis
Eosinophilic Neoplasms and Hypereosinophilic Syndrome
Systemic Mastocytosis
Lymphoproliferative Disorders
Diagnosis and Classification of Lymphomas
Molecular Genetic Aspects of Non-Hodgkin Lymphomas
Non-Hodgkin Lymphomas in Adults
Non-Hodgkin Lymphomas in Children
Chronic Lymphocytic Leukemia
Cutaneous T-Cell Lymphomas: Mycosis Fungoides and Sezary Syndrome
Hodgkin Lymphoma in Adults
Hodgkin Lymphoma in Children
Plasma Cell Dyscrasias
Practical Approach to Evaluation of Monoclonal Gammopathies
Molecular Genetic Aspects of Plasma Cell Disorders
Monoclonal Gammopathies of Undetermined Significance and Smoldering Multiple Myeloma
Multiple Myeloma
Immunoglobulin Light-Chain Amyloidosis (Primary Amyloidosis)
Waldenstrom Macroglobulinemia
Poems Syndrome, Cryoglobulinemia, and Heavy-Chain Disease
Transplantation
Hematopoietic Cell Transplantation
Hematopoietic Stem Cell Transplantation for Nonmalignant Disorders
Allogeneic Hematopoietic Stem Cell Transplantation (HCT) for Hematologic Malignancies
Graft-Versus-Host Disease and Graft-Versus-Tumor Response
Late Effects After Transplantation