Kobeissy Firas H. Psychiatric Disorders: Methods and Protocols

Humana press: Springer Protocols, 2012 - 625 pages , ISBN: 1617794570
Series: Methods in Molecular Biology, №829
New high throughput techniques in neuroscience and psychiatry have enhanced the development of experimental, customizable animal models that are predictive of human neuropsychiatric pathology and give vital insights on the mechanisms and pathways involved. In Psychiatric Disorders: Methods and Protocols, key experts have written integrated chapters on neuropsychiatric research sharing their insightful expertise and opinions focusing on both the animal models as well as the cutting edge techniques applied. Beginning with an overview of the animal research in psychiatric illness and substance abuse, this comprehensive volume continues with the modeling of neuropsychiatric illness, drug abuse paradigms and techniques, biomarker identification, autoimmune inflammatory response, and neuroendocrine alteration in the areas of psychiatry, as well as state-of-the-art Omics approaches and neurosystems biology/data mining techniques to compute and analyze genomic and proteomics alteration occurring within neuropsychiatric models. As a part of the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
Thorough and easily applicable, Psychiatric Disorders: Methods and Protocols offers the detailed and clearly illustrated tools necessary for neuroscientists and psychiatrists to handle many unanswered scientific questions with a more creative and insightful approach.Overview of the Animal Research in Psychiatric Illness and Substance Abuse
New Frontiers in Animal Research of Psychiatric Illness
Experimental Psychiatric Illness and Drug Abuse Models: From Human to Animal, An Overview
Qualitative Vs. Quantitative Methods in Psychiatric Research
Methods in Animal Models of Psychiatric Illness
Animal Models of Self-Injurious Behavior: An Overview
Rodent Models of Adaptive Decision Making
Animal Models of Depression and Neuroplasticity: Assessing Drug Action in Relation to Behavior and Neurogenesis
Modeling Depression in Animal Models
Behavioral Model for Assessing Cognitive Decline
The Pemoline Model of Self-Injurious Behavior
Modeling Risky Decision Making in Rodents
Modeling Open Space Anxiety Test in Rodents: The Elevated Platform with Steep Slopes
An Animal Model to Study the Molecular Basis of Tardive Dyskinesia
Methods in Animal Models of Substance Abuse
Models of Chronic Alcohol Exposure and Dependence
Rat Models of Prenatal and Adolescent Cannabis Exposure
Modeling Nicotine Addiction in Rats
Animal Models of Nicotine Withdrawal: Intracranial Self-Stimulation and Somatic Signs of Withdrawal
Methods in Drug Abuse Models: Comparison of Different Models of Methamphetamine Paradigms
Cocaine Self-Administration in Rats: Hold Down Procedures
Cocaine Self-Administration in Rats: Discrete Trials Procedures
Cocaine Self-Administration in Rats: Threshold Procedures
Assessing Locomotor-Stimulating Effects of Cocaine in Rodents
Methods in Tobacco Abuse: Proteomic Changes Following Second-Hand Smoke Exposure
Methods in Animal Models of Eating Disorders
Animal Models of Sugar and Fat Bingeing: Relationship to Food Addiction and Increased Body Weight
Animal Models of Overeating
The Activity-Based Anorexia Mouse Model
Biomarkers, Neuroendocrine and Inflammatory Profiles Relevant to Neuropsychiatric Disorders
Dissociating Behavioral, Autonomic, and Neuroendocrine Effects of Androgen Steroids in Animal Models
Interleukin-2 and the Septohippocampal System: Intrinsic Actions and Autoimmune Processes Relevant to Neuropsychiatric Disorders
Experimental Schizophrenia Models in Rodents Established with Inflammatory Agents and Cytokines
P11: A Potential Biomarker for Posttraumatic Stress Disorder (PTSD)
Omics Analysis and Systems Biology Applications in Psychiatric Disorders
Investigation of Age-Specific Behavioral and Proteomic Changes in an Animal Model of Chronic Ethanol Exposure
Quantitative Peptidomics to Measure Neuropeptide Levels in Animal Models Relevant to Psychiatric Disorders
ADHD Animal Model Characterization: Transcriptomics and Proteomics Analyses
Psychiatric Disorder Biomarker Discovery Using Quantitative Proteomics
Gene Profiling of Laser-Microdissected Brain Regions and Individual Cells in Drug Abuse and Schizophrenia Research
Stable Isotope Labeling with Amino Acids in Cell Culture (SILAC)-Based Proteomic Analysis of Ethanol-Induced Protein Expression Profiles in Microglia
Systems Biology in Psychiatric Research: From Complex Data Sets Over Wiring Diagrams to Computer Simulations
Data Mining in Psychiatric Research